As a general rule with medication if a drug is taken daily then it takes 5 days to get to a steady level and 5 days to clear the system
PMID 23052696
NICE guidance (NG238) supports statin use for cardiovascular disease prevention in people with NAFLD
Additional neurotrophic factors, including insulin-like growth factor 1 (IGF-1) and nerve growth factor (NGF), exert complementary effects by regulating cellular metabolism, promoting anti-apoptotic pathways, and enhancing myelination [239, 240]
Robert Kushner, Professor of Medicine at Northwestern University, explains: "We consider the patients goals and values into account along with discussions of risk and benefits." This means your tapering plan will be unique to your situation, even if youre on the same medication as someone else
At the same time, compelling cardiovascular outcomes data will be equally critical for commercial success to demonstrate value to health systems: Novos SELECT trial read out in 2023, demonstrating the impact of Wegovy-induced weight loss was a statistically significant 20% reduction in a composite endpoint consisting of cardiovascular death, non-fatal myocardial infarction, or non-fatal stroke in 17,604 overweight or obese patients with prior cardiovascular disease
